Faith Statement

don want to be only person cured of HIV

Early reports identified him only as Berlin patient. But Timothy Ray Brown, the first person cured of HIV, was born and raised in Seattle.

Now, Brown is returning to his hometown to help boost efforts at the Fred Hutchinson Cancer Research Center and elsewhere to extend the cure to others.

don want to be the only person in the world cured of HIV, Brown said in an interview. want there to be a lot more like me. Seattle is also the first stop on his national fundraising tour for The Timothy Ray Brown Foundation, devoted to the search for a cure. Open triumphGolfers give bad reviews of Chambers Bay course, USGA says it’s just fineCool Seattle places off the tourist pathNine time major winner Gary Player calls Chambers Bay a ‘tragedy’Commuters: Seattle area traffic stinks, but we’d rather drive alone

really believe that there is going to be a cure for everyone within my lifetime, said Brown, 47.

His own cure was a grueling procedure that required a combination of serendipity and scientific innovation difficult to duplicate.

Diagnosed with HIV in 1995, Brown kept the disease mostly in check with a regimen of drugs. Then in 2006, while living in Berlin, he began to feel so weak he could barely ride his bicycle to work.

German doctors diagnosed a highly lethal form of leukemia.

Brown first stroke of luck was coming under the treatment of bone marrow transplant expert Dr. Gero H knew that about one in 100 Northern Europeans carry a genetic mutation that blocks the AIDS virus from getting into their immune cells, cheap jerseys china shielding them from infection. Since a bone marrow transplant basically involves killing off the patient defective immune system cheap jerseys with radiation and chemotherapy, and replacing it with one from a donor, H wondered if using a donor with the protective mutation might rid Brown of HIV at the same time it cured his leukemia.

Out of more than 2.5 people in Germany donor registry, H found 267 tissue matches to Brown and one person who also carried the mutation. But the benefits from the first transplant didn last, and Brown cancer came roaring back.

The donor, a German man living in the United States whom Brown has never met, agreed to a second transplant. H warned Brown there was a high likelihood the procedure would kill him and it nearly did.

became delirious. I couldn walk and I was incontinent, Brown cheap nfl jerseys from china recalled. When a physical therapist told him to lift his left leg, he lifted the right. couldn tell the difference anymore. spent most of 2008 in the hospital. But every time H tested him for HIV, the tests came up blank. Today, Brown no longer takes drugs for HIV, and no tests have detected virus anywhere in his body.

Most AIDS experts agree that his cure is real, though some suspect virus may still be lurking in some cells. Brown himself didn believe he was cured until H published a paper about the case in the New England Journal of Medicine in 2009.

that point I thought, medical scientists are accepting it, so it must be true, Brown said.

In April, a 12 year old boy with HIV received a transplant in Minnesota using umbilical cord blood from a newborn with the protective mutation but it too early yet to know if the procedure provided a cure.

Clearly, though, it not the kind of operation that can be widely replicated, said Hutch researcher Dr. Keith Jerome.

Jerome and his colleagues hope to develop a streamlined version of Brown cure. long term goal is to make this simple enough that it doesn require hospitalization, Jerome said.

With a $20 million grant from the National Institutes of Health (NIH), the Hutch scientists are tweaking patients own stem cells to make them resistant to HIV.

To do that, they use special enzymes developed by California based Sangamo BioSciences to induce cheap nhl jerseys artificial mutations that mimic those in people who are naturally immune to the virus.

an engineering tour de force, Jerome said. some ways, it seems like science fiction that we can actually modify a spot in the genome and leave everything else alone.

The research is still in an early stage, but the scientists hope to start clinical trials soon.

In a sign of the growing optimism about a cure, two other labs also received major NIH grants at the same time as the Hutch. Scientists at the University of California, San Francisco, are working to rev up patients immune systems to fight the virus. At the University of North Carolina, the focus is on drugs that will roust out hidden pockets of infection.

Other scientists think early, aggressive treatment of HIV might be able to eliminate the virus. That what happened with a baby in Mississippi who was born infected. Doctors immediately administered high doses of drugs. More than two years later, the child seems to be HIV free.

Brown, who now lives in Las Vegas, says he healthy and plans to spend much of the summer in Seattle, where his mother still lives. After coming out as gay in the 1980s, he was an AIDS activist in Seattle long before his diagnosis.Articles Connexes：

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